SYRE

$43.95

Post-MarketAs of Mar 17, 8:00 PM UTC

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases.

Historical Price

Price (Line)
50-Day SMA
200-Day SMA
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Peer Comparison

JNJUNHPFE

Whystock Valuation Model

Calculated using a trailing P/E relative model adjusted by sector ROE and historical growth.
Current Price$43.95
Potential Upside
5%
Whystock Fair Value$46.15
Price
UndervaluedFair ValueOvervalued

Fundamentals

SectorHealthcare
IndustryBiotechnology

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin ...

Market Cap
Total dollar market value of a company's outstanding shares of stock (Price * Shares).
$3.45B
P/E Ratio
Priced for growth. Investors expect sustained double-digit expansion.
-
Beta
High-beta play. Expect amplified moves vs. the broad market.
3.12
Div Yield
Low to zero yield. Return is entirely dependent on price appreciation.
0.00%
ROIC
Average efficiency. Growth may require heavy reinvestment.
-25.17%
Quick Ratio
Pristine liquidity. Sufficient cash to cover all near-term obligations.
12.94

Recent News

Motley Fool
Mar 15, 2026

VR Adviser Adds Over 1 Million Savara Shares

This clinical-stage biotech develops inhaled therapies for rare respiratory diseases, with its lead candidate in Phase III trials.

BULLISH
Positive press. Headlines skewed toward growth and analyst upgrades.
Simply Wall St.
Mar 5, 2026

Assessing Spyre Therapeutics (SYRE) Valuation After A Year Of Strong Shareholder Returns

Why Spyre Therapeutics Stock Is On Investors’ Radar Spyre Therapeutics (SYRE) has attracted attention after a strong share price move over the past year, alongside meaningful swings in shorter term returns that may prompt investors to reassess risk and reward. See our latest analysis for Spyre Therapeutics. Recent trading has been choppy, with a 2.32% 1 day share price return and a 6.56% 7 day share price decline. However, a 25.19% 30 day share price return and a 110.58% 1 year total...

BULLISH
Positive press. Headlines skewed toward growth and analyst upgrades.
Motley Fool
Feb 23, 2026

From Sizable Stake to Zero: The Likely Reason Why Agios Shares Lost a $94 Million Backer

Agios Pharmaceuticals develops therapies for rare blood disorders, anchored by its PYRUKYND franchise and early-stage clinical programs.

NEUTRAL
Neutral flow. Standard news cycle with no clear sentiment tilt.
Motley Fool
Feb 23, 2026

Viridian Therapeutics Stock Up 75%, but One Fund Just Sold Off Its $69 Million Stake

Viridian Therapeutics develops monoclonal antibody therapies targeting rare diseases, with a focus on thyroid eye disease treatments.

NEUTRAL
Neutral flow. Standard news cycle with no clear sentiment tilt.
Motley Fool
Feb 23, 2026

Spyre Therapeutics Stock Surges This Past Year as $10.5 Million Buy Lifts Stake to $78 Million

Spyre Therapeutics develops preclinical monoclonal antibody therapies targeting inflammatory bowel disease and related conditions.

NEUTRAL
Neutral flow. Standard news cycle with no clear sentiment tilt.