UPB

$9.71

Pre-MarketAs of Mar 17, 8:00 PM UTC

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders.

Historical Price

Price (Line)
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Peer Comparison

JNJUNHPFE

Whystock Valuation Model

Calculated using a trailing P/E relative model adjusted by sector ROE and historical growth.
Current Price$9.71
Potential Upside
5%
Whystock Fair Value$10.20
Price
UndervaluedFair ValueOvervalued

Fundamentals

SectorHealthcare
IndustryBiotechnology

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 clinical development for the treatment of severe asthma and c...

Market Cap
Total dollar market value of a company's outstanding shares of stock (Price * Shares).
$524.71M
P/E Ratio
Priced for growth. Investors expect sustained double-digit expansion.
-
Beta
High-beta play. Expect amplified moves vs. the broad market.
-
Div Yield
Low to zero yield. Return is entirely dependent on price appreciation.
0.00%
ROIC
Average efficiency. Growth may require heavy reinvestment.
-40.80%
Quick Ratio
Pristine liquidity. Sufficient cash to cover all near-term obligations.
31.47

Recent News

MarketBeat
Feb 16, 2026

Upstream Bio Shares Phase II VALIANT Data: Verekitug Cuts Severe Asthma Exacerbations Up to 56%

Upstream Bio (NASDAQ:UPB) reported top-line results from its Phase II VALIANT trial evaluating verekitug in adults with severe asthma, highlighting statistically significant reductions in annualized asthma exacerbation rate (AAER) with multiple dosing regimens and a safety profile the company said w

BEARISH
Negative press. News cycle fixated on risk factors or misses.
Simply Wall St.
Feb 15, 2026

Companies Like Upstream Bio (NASDAQ:UPB) Are In A Position To Invest In Growth

We can readily understand why investors are attracted to unprofitable companies. For example, although Amazon.com made...

BULLISH
Positive press. Headlines skewed toward growth and analyst upgrades.
Clinical Trials Arena
Feb 12, 2026

Upstream Bio’s stock drops 47% on verekitug Phase II asthma data

Investors pull away from Upstream as a twice-yearly dose of verekitug fails to match Tezspire’s efficacy in reducing asthma exacerbations.

BEARISH
Negative press. News cycle fixated on risk factors or misses.
Investor's Business Daily
Feb 11, 2026

Upstream Bio Crashes After Asthma Drug Succeeds — With The Wrong Dose

Shares of Upstream Bio crashed Wednesday after the biotech's asthma drug succeeded in Phase 2 study, but with a more frequent dosing regimen.

BULLISH
Positive press. Headlines skewed toward growth and analyst upgrades.
BioPharma Dive
Feb 11, 2026

Evommune rockets on eczema data; AstraZeneca advances GLP-1 pill

Shares of Evommune nearly doubled on data suggesting it has a potential threat to Dupixent. Elsewhere, a closely watched narcolepsy drug got an FDA decision date and investors scrutinized Upstream’s asthma results.

BEARISH
Negative press. News cycle fixated on risk factors or misses.
UPB Stock Analysis & Real-Time Data | Whystock